Tae-In Kam 00:00:05
Hi, my name is Tae-In Kam from Johns Hopkins University. I'm an assistant professor in the Department of Neurology.
My research is related to the molecular mechanisms of Parkinson's disease induced by the alpha-synuclein protein, the main cause of Parkinson's disease. While pathological accumulation of aggregated alpha-synuclein protein is a main cause of Parkinson's disease, how this aggregated alpha-synuclein protein causes neurodegeneration is largely unknown. We originally found that alpha-synuclein protein induces neural cell death in a PARP-1-dependent manner, which means that targeting PARP-1 inhibition could be a new therapeutic target for Parkinson's disease.
With research support from the Parkinson's Foundation, I propose to identify the two novel regulators of the PARP-1 enzyme. One is the upstream regulator that regulates the activity of PARP-1, and the other is the downstream regulator that is activated and actually causes neural cell death after PARP-1 activation. From our research, we will provide new, multifaceted therapeutic targets against neural cell death in Parkinson's disease.
Tae-In Kam 00:01:25
Let's go back to our original paper, which was published in Science in 2018. PARP-1 is an enzyme that is activated during the DNA damage response under normal conditions. We first identified that alpha-synuclein aggregates caused hyperactivation of PARP-1 in response to the high accumulation of DNA damage stress. Interestingly, PARP-1 inhibition showed drastic reductions of parkinsonism pathologies, including neuronal cell death, decreased dopamine levels and movement behavior deficits, which means inhibiting PARP-1 is critical for Parkinson's pathogenesis.
I think the most hopeful aspect for my work with Parkinson's disease is the potential for positive impacts on the disease. The progress brings hope for improved treatments or some quality of life for those who are affected by Parkinson's disease.
The Parkinson's Foundation provides critical support for my laboratory efforts to tackle the big questions in Parkinson's disease: what is the fundamental molecular mechanism of Parkinson's disease? Your support provides a critical catalyst for developing my research program to pursue interesting and quite innovative research. With the help of your support, I will take a big step to be a leader in this field.
The Parkinson’s Foundation drives a multi-disciplinary research strategy to close the gaps in knowledge about Parkinson’s – from its basic biology to its impact on the brain and its effects on people. We work to accelerate our findings, quickly applying them to improved treatments and care today.
We spur discovery by taking a comprehensive, big-picture approach to research. This approach is vital to identifying the fastest lanes to new therapies for the 10 million people living with Parkinson's in the world.
Join us to discuss Parkinson's symptoms, treatments, and progression while we explore important factors in helping live your best life, including diet, exercise, and staying connected. This program will also feature a live Q & A with Parkinson's experts.
Expert Speakers:
Mitesh Lotia, MD
Medical Director of Movement Disorders | AdventHealth
Ramón Rodríguez, MD, FAAN Medical Director, Neurology One
Víctor Lameda, MD Clinical Research Coordinator, Neurology One
People with Parkinson's and Care Partner Panel
JoAnn Hartge
Gary Appelsies
Moderator: Anna Moreno, MSW, Parkinson's Foundation, Senior Parkinson Information Specialist
Fitness Demonstration: Firebush, a Parkinson's Foundation Community Grant recipient.
Fitness Demonstration: PunchWorX, a Parkinson's Foundation Community Grant recipient.
For in-person attendees: Check-in and Resource Fair start at 9 a.m. Lunch will be served.
For virtual attendees via Zoom: The live stream starts at 10 a.m.
There is no charge to attend, but registration is required since lunch will be served. This program is open to people with Parkinson's, their family, friends and the community.
Parkinson’s Champions athletes raise funds and awareness for the Parkinson’s Foundation while competing in some of the world’s most popular races. Every step we take brings us closer to a future without Parkinson’s disease, because Parkinson’s isn’t a sprint, it’s a marathon.
Through guided breathwork and visualization, you will be encouraged to step into the present by releasing thoughtful roadblocks and opening your mind to new opportunities and experiences that can assist in managing Parkinson’s disease.
Acompáñenos en un webinar informativo que explora la relación entre el dolor y la enfermedad de Parkinson. Esta sesión tiene como objetivo adentrarse en los diversos tipos de dolor asociados con la enfermedad de Parkinson, ya sea derivado de síntomas motores o manifestaciones no motoras.
Hablaremos sobre las estrategias prácticas para el manejo del dolor y mejorar su comprensión de cómo el dolor afecta la calidad de vida en general de aquellos afectados por la enfermedad de Parkinson.
Presentador
Dr. Daniel Martinez-Ramirez
Profesor, Investigador Nacional por México Nivel 2
Neurología, trastornos del movimiento
Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud
Instagram: @neurologoparkinson
Parkinson’s Champions athletes raise funds and awareness for the Parkinson’s Foundation while competing in some of the world’s most popular races. Every step we take brings us closer to a future without Parkinson’s disease, because Parkinson’s isn’t a sprint, it’s a marathon.
Through guided breathwork and visualization, you will be encouraged to step into the present by releasing thoughtful roadblocks and opening your mind to new opportunities and experiences that can assist in managing Parkinson’s disease.
26th Annual Blazing Toward a Cure Educational Symposium
9:00 am to 12:00 pm CDT
FREE
This event has reached capacity. To be added to the waitlist, please email tnky@parkinson.org.
Please join the Vanderbilt Medical Center and Parkinson’s Foundation Center of Excellence team for the 26th annual Blazing Toward a Cure educational symposium. Please register for this no cost educational opportunity.
This program will be held at the Vanderbilt Student Life Center (Nashville, TN), where free valet parking will be available. Doors open at 8:00 a.m. and the program will begin promptly at 9:00 a.m. Continental breakfast will be served at 8:30 a.m.
There is no charge to attend, but registration is required. This program is open to people with Parkinson's, their family, friends and the community.
Expert Speakers
Thomas L. Davis, MD
Division Chief/Movement Disorders,VUMC
Parkinson’s Champions athletes raise funds and awareness for the Parkinson’s Foundation while competing in some of the world’s most popular races. Every step we take brings us closer to a future without Parkinson’s disease, because Parkinson’s isn’t a sprint, it’s a marathon.
Through guided breathwork and visualization, you will be encouraged to step into the present by releasing thoughtful roadblocks and opening your mind to new opportunities and experiences that can assist in managing Parkinson’s disease.
8 Practical Ways to Work on Your Mental Health with Parkinson’s
For people with Parkinson’s disease (PD) and care partners, dedicating time to maintaining mental health can feel like its own battle. From the mental exhaustion leading up to a Parkinson’s diagnosis to what can feel like ever-changing symptoms as PD progresses, it’s easy for mental health to not be a priority.
Below we explore eight practical ways to work on your mental health. Most of these can be applied to people with PD and care partners, as both are constantly navigating the complexities of mental health symptoms alongside the physical ones.
1. Get to know the science behind the psychological impact of Parkinson's.
Depression, anxiety and apathy are all common Parkinson’s symptoms. In fact, up to 50% of people with Parkinson’s will experience some form of depression. Our research shows that together, depression and anxiety have the greatest impact on the health of people with PD, even more than the movement challenges.
The science behind mood symptoms is that Parkinson’s directly impacts the production of dopamine in the brain. Dopamine plays an essential role in helping the body move smoothly and the brain process emotions.
What can you do? Get to know non-movement symptoms. Learn the signs of depression. Bring up any mood-related symptoms to your Parkinson’s doctor. Together, you can find treatment options that work for you.
Research shows that exercise and physical activity can not only maintain and improve mobility, flexibility and balance but also ease non-movement PD symptoms. Exercise releases chemicals in the brain such as neurotransmitters and endorphins that make us feel good. It reduces immune system chemicals that can worsen depression, and it increases body temperature, which may have a calming effect.
PD-tailored exercises classes, from non-contact boxing to indoor cycling, are excellent forms of exercise and have the bonus of helping build your PD support system.
Increasing physical activity alone was shown in some studies to improve mood. Walking, gardening, housework, washing the car — any activity that gets you moving can help improve your mood. Even adding small amounts of physical activity throughout your day can be useful.
Resource that can help: Try an on-demand exercise class through our Fitness Friday videos, or call our Helpline at 1-800-4PD-INFO (1-800-473-4636) to find a PD-tailored exercise class near you.
3. Try complementary therapies.
Explore holistic approaches that can support mental wellness in addition to your treatment plan. About 40% of people with Parkinson’s use some type of complementary therapy as part of their regular treatment routine.
Eating a whole food, plant-based diet, often called the Mediterranean diet, can help you live well with PD. Eat what you need to be happy — but also eat more of the food that is good for your health.
If you have Parkinson’s, every healthy lifestyle change can help. While it can be challenging to eat better, most people make minor diet changes gradually that become major changes over time. Always consult your physician before making major changes.
5. Attend an in-person event and try a new resource.
For everyone, finding the tools that help you cope with stress and anxiety can be a lifelong endeavor. Explore Parkinson’s Foundation resources that can help you get the support you need.
How can I support my loved one with Parkinson’s through mental health changes? How can I support my own mental health? As a caregiver, you have a dual role — taking care of the person with Parkinson’s and taking care of yourself. These roles are equally important! A strong personal support network will help you have an outlet for your emotions and be able to take time off. Call our Helpline at 1-800-4PD-INFO (1-800-473-4636) to find a local caregiver support group.
Regularly check in with yourself. Seek help professionally or from a trusted friend as you need it. Remember to take breaks — utilize people in your life, or external resources, to allow you respite from caregiving.
7. For everyone: Build your mental health support team.
Recognizing your individual emotional needs and building a strong support network that includes mental health professionals is part of a comprehensive plan to navigate PD.
Surround yourself with people who will listen, uplift and encourage you when you need them. Look for support among your friends, family and community. Take the time to find the right therapist. It may be difficult to find one familiar with PD, but those who are specialized in chronic illness, grief, anxiety and depression can often address common feelings and experiences of living with a PD diagnosis.
8. For everyone: Call our Helpline for personalized resources and tools.
Our Helpline is here to answer your Parkinson’s questions. Speak to our Helpline specialists to find resources that work best for you or your loved one with Parkinson’s. Regarding mental health, our Helpline can provide referrals to:
Healthcare professionals.
Community resources including exercise classes and local support groups.
Mental health resources.
Resource that can help: Call 1-800-4PD-INFO (1-800-473-4636) or emailHelpline@Parkinson.org.
7 de los principales recursos bilingües acerca del Parkinson
Vivir bien con la enfermedad de Parkinson (EP) significa obtener el apoyo que necesita: desde herramientas que le ayuden a trabajar junto con su equipo de atención médica hasta recursos que lo empoderen. La Parkinson’s Foundation es su aliada de confianza para obtener información que puede ayudarle a navegar por cada etapa de esta enfermedad.
¿Sabía que nuestros 7 recursos principales están disponibles en inglés y español? Explore a continuación estos recursos diseñados para ayudar a facilitarle un poco más la vida a las personas con la enfermedad de Parkinson, a sus cuidadores y a sus familiares:
1. Línea de Ayuda
Llame al 1-800-4PD-INFO (1-800-473-4636), opción 3 para español o envíe un correo electrónico a Helpline@Parkinson.org para hacer sus preguntas sobre la EP a un especialista de la Línea de Ayuda, de lunes a viernes de 9 a.m. a 7 p.m., hora del Este.
Visite nuestrositio web para consultar un número ilimitado de artículos dedicados a la información más reciente sobre el Parkinson. Consulte nuestras páginas más populares: 10 signos, Etapas del Parkinson y Levodopa.
Inscríbase a un evento en línea diseñado para usted. ¿Listo para aprender algo nuevo ahora mismo? Explore nuestra impresionante colección de eventos grabados:
Visite nuestro blog para leer artículos que destacan los temas más recientes sobre el Parkinson: desde investigaciones hasta consejos para ayudarle a vivir mejor con el Parkinson.
Recuerde participar con nosotros en este Mes de la Concientización sobre el Parkinson compartiendo su ABC de la EP y lea nuestras ideas para publicaciones en redes sociales en nuestro kit de herramientas en español.
Educational Events
Learn More. Live Better. Parkinson’s Symposium
10:00 am to 1:30 pm CDT
FREE
Check-in & the Resource Fair (for in-person attendees) begins at 9:00 a.m. CDT
Living with Parkinson’s can be challenging, but there are many things you can do to maintain and improve your quality of life. This program will provide you with information to help you find the balance between a proactive approach and wondering what lies ahead.
Expert Speakers
Erin Edmundson, PT, DPT
Huntsville Hospital Parkinson's Care Clinic
Jay van Gerpen, MD, FAAN
Neurology Consultants of Huntsville
Carolina Parker, MD
Neurology Consultants of Huntsville
Brandi Ivey M.Ed, CPPN
Huntsville Hospital Parkinson's Care Clinic
Katelyn Bowden, OT
Huntsville Hospital Parkinson's Care Clinic
There is no charge to attend, but registration is required. This program is open to people with Parkinson's, their families, friends, and the community.
9 a.m. – 10:00 a.m.
Check-in & Resource Fair
10:00 a.m. – 10:10 a.m.
Welcome: Stacey Faber
Senior Director, Community Education & Outreach, Southeast
Parkinson’s Foundation
10:10 a.m. – 10:40 a.m.
Optimizing Your Parkinson’s Care
Carolina Parker, MD,
Neurology Consultants of Huntsville
10:40 a.m. – 11:00 a.m.
Question & Answer Session
11:00 a.m. – 11:15 a.m.
Movement Break
Clarissa Sharp, MPT
Traci Aday, LPTA
Parkinson’s Care Clinic, Huntsville Hospital
11:15 a.m. – 11:45 a.m.
Mind Your Mouth: Speech, Swallowing & Smiles in Parkinson’s
Anitra Ford, MS, CCC-SLP
Huntsville Hospital Therapy Services
12:30 p.m. – 1:10 p.m.
Let’s Get Uncomfortable:
The Parkinson’s Topics We Need to Talk About
Moderated By: Erin Edmunson, PT, DPT
Huntsville Hospital Parkinson’s Care Clinic
Jay Van Gerpen, MD, FAAN
Huntsville Hospital
Brandi Ivey, M.Ed, CPPN, Care Navigator
Parkinson’s Care Clinic, Huntsville Hospital
Kristi Holland, OT
Parkinson’s Care Clinic, Huntsville Hospital
Kristi Holland, OT
Parkinson’s Care Clinic, Huntsville Hospital
Parkinson’s Champions athletes raise funds and awareness for the Parkinson’s Foundation while competing in some of the world’s most popular races. Every step we take brings us closer to a future without Parkinson’s disease, because Parkinson’s isn’t a sprint, it’s a marathon.
Through guided breathwork and visualization, you will be encouraged to step into the present by releasing thoughtful roadblocks and opening your mind to new opportunities and experiences that can assist in managing Parkinson’s disease.
Parkinson's Disease Program for African American and Latinx Communities
10:00 am to 2:00 pm PDT
FREE
Join Stanford and UCSF for a free educational event for two under-served communities – the African American Parkinson’s community and the Latinx Parkinson’s community. There will be simultaneous sessions (different rooms) in English and Spanish.
Ideally for those diagnosed in the last few years. Family members and friends are welcome and encouraged to join!
Attendance is free, but registration is required and seating is limited. Lunch will be provided.
Expertos en el tratamiento de trastornos del movimiento hablarán en español acerca de los sintomas y el manejo de la enfermedad de Parkinson y se dará información acera de agencias en la comunidad que ofrecen grupos de apoyo y programa de ejercicio.
Este programa es gratuito y está disponible para cualquier persona interesada, incluyendo a las personas con Parkinson y sus familiares, amigos, aliados de cuidado y promotores de salud.
Sponsored by the Parkinson's Foundation and hosted by UCSF Movement Disorders and Neuromodulation Center & Stanford Movement Disorders Center. Both are Parkinson's Foundation Centers of Excellence.
Parkinson’s Champions athletes raise funds and awareness for the Parkinson’s Foundation while competing in some of the world’s most popular races. Every step we take brings us closer to a future without Parkinson’s disease, because Parkinson’s isn’t a sprint, it’s a marathon.
Through guided breathwork and visualization, you will be encouraged to step into the present by releasing thoughtful roadblocks and opening your mind to new opportunities and experiences that can assist in managing Parkinson’s disease.
Parkinson's Foundation Launches: The PD Solo Network - Living Alone While Living with PD
There are two sessions available: You are welcome to choose one or attend both.
– 1 p.m. to 2:30 p.m. ET
– 7:30 p.m. to 9 p.m. ET
What is the PD Solo Network:
A virtual network for people living with Parkinson's disease (PD) who live alone, by choice or circumstance. The purpose of this group is to create a community of support for those living without a care partner. People living with PD are the experts about what challenges, changes and accommodations are needed on a daily basis. This network will provide a place to share ideas, concerns, brainstorm strategies, suggestions, resources & to build relationships.
The Parkinson's Foundation is providing the initial funding and support to kick start this network. It will most likely become a very strong network that will operate independently although the Parkinson's Foundation will always be an entity of support & information for the participants.
Upcoming Meeting Dates:
– February 13 and February 27, 2024
– March 12 and March 26, 2024
– April 9 and April 23, 2024
There is no charge to attend, but registration is required in order to receive the Zoom link.
Parkinson’s Champions athletes raise funds and awareness for the Parkinson’s Foundation while competing in some of the world’s most popular races. Every step we take brings us closer to a future without Parkinson’s disease, because Parkinson’s isn’t a sprint, it’s a marathon.
Through guided breathwork and visualization, you will be encouraged to step into the present by releasing thoughtful roadblocks and opening your mind to new opportunities and experiences that can assist in managing Parkinson’s disease.
