Podcasts

Episode 115: Repurposing Medications to Slow Progression of PD

Until the ultimate goal of finding a cure for Parkinson’s disease (PD) is achieved, researchers are taking various approaches to developing a treatment that significantly slows its progression. Here, clinical science and basic science come together to understand the underlying biological mechanisms of PD and then using that knowledge to test medications that target those mechanisms. Having discovered such molecular and cellular malfunctions, scientists may tailor the development of medications to target the underlying causes of the disease.

Another approach has also relied on knowing the mechanisms of the disease but then searching through the vast array of current drugs to treat all sorts of conditions and rationally choosing ones that may work to slow progression of PD – so-called drug repurposing. Dr. Patrik Brundin, Director of the Parkinson’s Disease Center at Van Andel Institute in Grand Rapids, Michigan, explains that this is the approach that the International Linked Clinical Trials (iLCT) program for Parkinson’s has taken. Since its inception in 2010, the iLCT has become one of the most comprehensive drug repurposing programs focused on a single disease. Under this program, seven clinical trials have been completed, and 15 are ongoing, testing 16 potential candidate drugs to slow the progression of PD. The advantage is that the drugs under consideration have already been tested for safety and how they act in the body, speeding up the process of applying them to Parkinson’s.

Released: October 19, 2021

Podcasts

Episode 114: Gene-Based Therapies for Parkinson’s Disease

Gene-based therapies for Parkinson’s disease, while still in the developmental stage, are under active investigation. For this potential therapy, genes are engineered in a laboratory and then injected into specific parts of the brain. The genes may function either to induce cells in the brain to produce dopamine, or to code for the production of enzymes that then lead to the production of dopamine.

This episode is the second part of our conversation with Dr. Roger Barker, Professor of Clinical Neuroscience at the University of Cambridge in the United Kingdom. In our previous podcast with him, he discussed cell therapy for Parkinson’s. Here, he explains what gene-based therapy is, plans for the execution of the treatments, what symptoms they are aimed at, where the field currently stands, and how it compares to developments in cell-based therapies. As the field is still in the experimental stages, he again offers advice to people with Parkinson’s who are considering entering a clinical trial of gene-based or cell-based therapy and what they may expect in terms of symptom management and disease progression.

Released: October 5, 2021

Podcasts

Episode 89: Retention Rates in Longer Clinical Studies

Clinical studies, studies that involve people, first use healthy people to test a drug’s safety and then use people with a disease or condition to prove that the drug works as intended. They are essential for bringing any new therapy to the public. Getting U.S. Food and Drug Administration approval for devices require rigorous studies, as well. Recruiting enough people to participate is often a long process, and for trials that may go on for a year or more, retaining people in the studies is often a challenge. People may get bored, find multiple study visits burdensome, have an adverse reaction to a drug being tested, move away, or drop out for a multitude of other reasons. If too many people discontinue the study, it will not have enough statistical ”power” to give a meaningful answer when the data are analyzed.

Christine Hunter, BSN, RN, Research Director of the Parkinson’s Disease Center and Movement Disorders Clinic at Baylor College of Medicine in Houston, a Parkinson’s Foundation Center of Excellence, describes how her center finds people with Parkinson’s disease who may want to participate in trials, what factors drive retention in trials, and ways to facilitate retention.

Released: September 8, 2020

Podcasts

Episode 88: The Skinny on Clinical Trials in PD

When people take a prescribed drug, they rarely if ever consider how it came to be. They assume it is the right drug and will work safely as it is supposed to. But leading up to that drug being available is a long process of discovery or invention of the molecule based on knowledge of the biology it is supposed to affect, then testing in the laboratory and in animals, and several phases of testing in people to make sure that it is safe and effective. Each of these steps takes time and lots of financial investment. Even after a drug is approved by the U.S. Food and Drug Administration for sale and then put on the market, further study of the drug in a larger population than in the testing phases may be carried out. In this episode, Dr. Hubert Fernandez, Director of the Center for Neurological Restoration at the Cleveland Clinic in Ohio, a Parkinson’s Foundation Center of Excellence, describes the process of bringing a drug to market, including how many of them never make it. And he explains why people need to participate in the clinical trials and what they can expect when they do.

Released: August 25, 2020

Videos & Webinars

Neuro Talk: Why Are More People Getting Diagnosed with Parkinson’s?

The number of people diagnosed with Parkinson’s disease (PD) in the U.S. recently increased by 50%, according to a new study. What do these results mean for the PD community?

In this Neuro Talk, Parkinson's Foundation Chief Scientific Officer James Beck, PhD, shares results from this groundbreaking study on Parkinson’s disease incidence. Dr. Beck also highlights how the new incidence number will impact PD research.

Podcasts

Episode 86: Personalized Medicine: The Voice of the Patient

Personalized medicine has garnered a lot of attention over the past decade. Usually it means determining the factors for each person that affect their health, their diseases, and potentially their treatments. Some examples are biomarkers that are found in their blood, their genetic make-up, diet and nutrition, behaviors, and environment. One example is the Parkinson’s Foundation’s PD GENEration initiative that offers free genetic testing and counseling for people with Parkinson’s disease (PD) to determine what genes and gene variants affect the course of their disease and response to treatments.

But despite all the scientific advances that allow these forms of personalized medicine, one crucial aspect of personalized medicine is the voice of the patient, both in each person’s encounters with the medical system and treatment team, as well as to inform the kinds of research that should be done and how to design and perform them. Dr. Bas Bloem, a professor of movement disorder neurology at Radboud University Medical Center in Nijmegen, the Netherlands, a Parkinson’s Foundation Center of Excellence, discusses how people with PD want to be heard and how a new definition of health may best put people’s disease into the overall context of their lives.

Released: July 28, 2020

Videos & Webinars

Expert Briefing: Can We Put the Brakes on Parkinson's Disease Progression?

April 6, 2022

Discovering the right treatments, interventions and support can enhance your quality of life with Parkinson’s disease (PD), but can it slow progression? Learn what the latest research is saying about slowing Parkinson’s progression including the most promising treatment and day-to-day adjustments. This program will also review how care and treatment strategies are adapted based on lessons learned from the Parkinson’s community.

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Presenter

Joash Lazarus, MD
Multiple Sclerosis Center of Atlanta

Videos & Webinars

Neuro Talk: Propelling a Future of New Parkinson’s Drugs Through Research

We know that research is an essential part of finding a cure for Parkinson’s disease (PD), but how can we speed up the process? In our latest Neuro Talk, Parkinson's Foundation Chief Scientific Officer James Beck, PhD, discusses the Venture Philanthropy Fund — our newest research-driven investment fund. Dr. Beck explains why Parkinson’s research is underfunded and shares how the Venture Philanthropy Fund is working to accelerate the breakthroughs in treatments that people with PD need today.

Podcasts

Episode 25: Meet the High School Student Who Is Changing Parkinson's Disease Diagnosis

There is no single, definitive test for Parkinson’s disease (PD). The diagnosis is made by an expert clinician who asks questions about a person’s health and medical history and observes their movement. But an enterprising high school student is working on a system that analyzes movements of facial muscles to make an early diagnosis and track Parkinson’s progression. Erin Smith of Shawnee Mission West High School in the Kansas City, Kansas area adapted a real-time facial expression recognition system to detect “facial masking,” a common Parkinson’s symptom caused by stiff facial muscles. Her system, called FacePrint, uses a web camera or smartphone to analyze facial movements and compare them to a database of people with and without Parkinson’s.

Released: March 27, 2018

Podcasts

Episode 24: Donate Your Brain for Parkinson’s Research

Despite great advances in genetics and molecular biology, many aspects of research on diseases affecting the brain, including Parkinson’s, still depend on actual human brain tissue for study. How do researchers get these brains for study? They need you to become a brain donor! It is important for people with neurological diseases to donate their brains after death, but healthy brains are also needed for comparison. Brain retrieval must occur very quickly to be useful, so advance planning is essential. Tish Hevel, founder and CEO of the Brain Donation Project, explains how to become a brain donor, and she dispels some misperceptions about the subject.

Released: February 27, 2018

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