Activating Specific Brain Cells Points to New Strategies for Parkinson’s Therapy

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Author
Parkinson's Foundation

All Science News articles summarize a research study and are not an official opinion, endorsement or position of the Parkinson’s Foundation’s.

In experiments with mice, scientists were able to activate certain brain cells to ease movement symptoms similar to those of Parkinson’s disease (PD). The results may help explain the effects of deep brain stimulation (DBS) surgery on Parkinson’s symptoms, and may pave the way to developing longer-lasting therapies. The study appears in the May 8 online edition of Nature Neuroscience.

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Science News

What's Hot in PD? Is DBS Plus a Viable Future Treatment for Parkinson’s Disease?

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Author
Dr. Michael S. Okun

Over the past two decades, deep brain stimulation (DBS) therapy for patients with Parkinson’s disease (PD) has been extremely successful. It has been estimated that DBS has meaningfully helped tens of thousands of patients worldwide, improving tremor, dyskinesia, “on-off” fluctuations and several other Parkinson’s symptoms. DBS has however, fallen short in addressing disease progression issues including walking, talking and thinking.

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What's Hot in PD?

Parkinson’s-Linked Genetic Mutations More Common With Deep Brain Stimulation

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Author
Parkinson's Foundation

Among people with young-onset Parkinson’s disease (PD), a new study finds that those who underwent deep brain stimulation (DBS) surgery were more likely to have a PD-linked genetic mutation than those who did not get DBS. The research represents a step forward in understanding how genetic mutations impact the symptoms and progression of PD, and, in turn, the benefits of DBS. The results appear in the September/October issue of Movement Disorders Clinical Practice.

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Science News

What's Hot in PD?: Current Steering and New Deep Brain Stimulation Technologies: What’s Here and What’s Coming

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Author
Dr. Michael S. Okun

A surprising fact about deep brain stimulation (DBS) surgery technology is that human DBS leads (the wire implanted in the brain and connected to the neurostimulator) and their four shiny, tiny contacts have not really changed much over the last two decades. One reason for the durability of DBS lead design has been the long-term beneficial effects of using this simple approach.

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What's Hot in PD?

FDA Approves St. Jude Medical Infinity DBS System for People with PD

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Author
Parkinson's Foundation

The Parkinson’s Disease Foundation (PDF) alerts the community that St. Jude Medical Infinity Deep Brain Stimulation (DBS) system has been approved by the US Food and Drug Administration (FDA) for the treatment of people living with Parkinson's. The manufacturer reports that its new system is designed to provide targeted control of Parkinson’s symptoms with fewer side effects. This new approval was announced by the manufacturer on October 6.

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Science News

FDA Approves Medtronic DBS Therapy for Early PD

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Author
Parkinson's Foundation

The Parkinson’s Disease Foundation (PDF) alerts the community that Medtronic deep brain stimulation (DBS) Therapy has been approved by the US Food and Drug Administration (FDA) for the treatment of Parkinson's disease (PD) in people with at least four years disease duration and with recent onset of motor complications, or motor complications of longer-standing duration that are not adequately controlled with medication. The therapy was developed in the 1990’s and approved in 2002 for treatment in people living with advanced Parkinson’s disease.

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Science News

New Deep Brain Stimulation Device Holds Promise for Better Therapy

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Author
Parkinson's Foundation

A new technique for delivering deep brain stimulation (DBS) may provide a way to individualize this therapy, and lessen side effects, for some people with Parkinson’s disease (PD). A study published in the July edition of Lancet Neurology found that the technique, which can deliver more focused electrical stimulation at higher levels, safely improved PD symptoms.

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Science News

What's Hot in PD? Leaps in Deep Brain Stimulation Technology

Date
Author
Dr. Michael S. Okun

One surprising fact in DBS technology is that the human deep brain stimulation (DBS) leads and the four shiny and tiny contacts on them have surprisingly not significantly changed for the last two decades. One reason for the durability of DBS lead design has been the long-term beneficial effects of utilizing this simple approach. There are however, compelling reasons to introduce new DBS lead designs into clinical practice. Each target in the brain is a different size, and therefore the volume of electricity pumped into that target should be tailored to the appropriate region.

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What's Hot in PD?

What's Hot in PD? Deep Brain Stimulation for Parkinson’s Disease: the Parkinson's Foundation Congratulates Mahlon DeLong and Alim-Louis Benabid and Looks to a Bright Future in Human Neural-Network Modulation

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Author
Dr. Michael S. Okun

Life for people with Parkinson’s disease (PD) was largely untenable until the late 1960’s discovery of dopamine replacement therapy (levodopa). Following the introduction of levodopa there were worldwide reports that began to surface about previously institutionalized patients who were waking up and returning home. A few years following levodopa’s introduction however, a new reality began to uncomfortably set in.

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What's Hot in PD?
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