Over the past two decades, deep brain stimulation (DBS) therapy for patients with Parkinson’s disease (PD) has been extremely successful. It has been estimated that DBS has meaningfully helped tens of thousands of patients worldwide, improving tremor, dyskinesia, on-off fluctuations and several other Parkinson’s symptoms. DBS has however, fallen short in addressing disease progression issues including walking, talking and thinking.
There has long been a fascination about the relationship between welding, mining and Parkinson-like symptoms. In this month’s What’s Hot blog and in my NEJM Journal Watch blog I explore this murky history and relationship. Doctors and health care professionals long ago identified a Parkinson-like syndrome that developed in welders and manganese miners. Manganese, the chemical, has been linked to Parkinson-like symptoms (also referred to as parkinsonism).
Considerable evidence has been mounting in support of a relationship between the gastrointestinal (GI) system and Parkinson’s disease (PD). Many pathologists and neurologists even believe that Parkinson’s may start in the gut, but this view remains speculative. Many GI symptoms, such as constipation, occur as prominent and disabling PD symptoms. In the July 2013 What’s Hot in PD? column, I addressed H.
A surprising fact about Deep Brain Stimulation (DBS) surgery technology is that human DBS leads (the wire implanted in the brain and connected to the neurostimulator) and their four shiny, tiny contacts have not really changed much over the last two decades. One reason for the durability of DBS lead design has been the long-term beneficial effects of using this simple approach.
How to Address Prominent, Caregiver Challenges, NPF and PDF Complete Merger to Form the Parkinson’s Foundation, Parkinson’s Outcomes Project Links Age to Increased Risk, of Caregiver Strain Caregiver Spotlight: Julie Beck, Top Questions and Answers from "Ask the Doctor", Caregiver Tips for Daily Living What’s Hot in Parkinson’s Disease?, Spotlight on Moving Day® Dallas/Fort Worth, Caregiver Self Quiz, NPF Legacy Society
Ted Dawson, PhD, and colleagues at the Johns Hopkins University, a National Parkinson Foundation Center of Excellence, have uncovered a potential new approach to treat Parkinson’s disease (PD). Researchers in Dawson’s laboratory focused on a protein called lymphocyte-activation gene 3, known as LAG3. This protein has been shown to be important in cell to cell transfers of α-synuclein (Lewy bodies), which is a protein found in the brain of a person with PD.
A recent press release from the National Institutes of Neurological Disorders and Stroke detailed exciting ongoing work aimed to uncover magnetic resonance imaging (MRI) techniques capable of tracking Parkinson’s disease (PD) progression. In this month’s What’s Hot in PD? column we will review the recent progress of MRI-based biomarkers for Parkinson’s diagnosis and progression, and discuss the importance of the findings, especially in the context of clinical trials.
Previous What’s Hot blogs have addressed the promise and challenge of developing biomarkers for Parkinson’s disease (PD). Several groups of researchers have been working on blood and imaging biomarkers to provide more information on Parkinson’s: diagnosis, prediction, monitoring and methods to measure progression. In this month’s What’s Hot blog, we examine a new approach that utilizes a urine sample to detect the presence of Parkinson’s disease activity.
A French group presented data at the 20th International Congress of Parkinson’s Disease and Movement Disorders in Berlin Germany last month. Their results suggested a strong link between farming, pesticides and risk of Parkinson’s disease. Sofiane Kab and her colleagues demonstrated that living in rural French regions with more crops was a high risk for the later developing Parkinson’s. The authors noted that these are typically regions where vineyards are located.
Topics include: NPF's landmark patient registry enrolls 8,000 Parkinson's patients, how ot help people with Parkinson's maintain identity and dignity, a day in the life of a center coordinator, top questions and answers from "Ask the Doctor," Tips for daily living, What's Hot in Parkinson's disease, spotlight on Moving Day in D.C., 2016 Fall event calendar, and supporting the future of Parkinson's care and research today.