Activating Specific Brain Cells Points to New Strategies for Parkinson’s Therapy

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Parkinson's Foundation

All Science News articles summarize a research study and are not an official opinion, endorsement or position of the Parkinson’s Foundation’s.

In experiments with mice, scientists were able to activate certain brain cells to ease movement symptoms similar to those of Parkinson’s disease (PD). The results may help explain the effects of deep brain stimulation (DBS) surgery on Parkinson’s symptoms, and may pave the way to developing longer-lasting therapies. The study appears in the May 8 online edition of Nature Neuroscience.

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Science News

Potential Parkinson’s Therapy Harnesses Immune System Cells

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Author
Parkinson's Foundation

Researchers have found the drug sargramostim, currently used to boost the immune systems of people undergoing chemotherapy, to be relatively safe in people with Parkinson’s disease (PD). This result opens the door to testing its ability to protect the brain cells affected by PD. The results of this small, phase I clinical trial appear in the March 23 online edition of npj | Parkinson’s Disease.

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Science News

Faulty Mechanism for Protecting Brain Cells May Underlie Parkinson’s

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Author
Parkinson's Foundation

A mechanism that protects brain cells from the effects of aging appears to be weakened in Parkinson’s disease (PD), according to research in the November 22, 2016 edition of Nature Communications. The results suggest that this mechanism may underlie to brain cell loss in Parkinson’s, and points to a new therapeutic approach: boosting the brain’s own protective processes.

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Science News

Researchers Identify Point-of-Entry for Toxins That Harm Brain Cells in Parkinson’s

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Author
Parkinson's Foundation

In the September 30 edition of Science, researchers say they have discovered how toxic protein clumps enter brain cells in Parkinson’s disease (PD) — by unlocking a molecular “door” called LAG3. They also showed that preventing the protein clumps (alpha-synuclein) from entering through this door could slow or prevent PD-like symptoms in mice, suggesting new strategies for therapies.

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Science News
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