Parkinson's Today Blog

What's Hot in PD? Keeping an Eye on Trials Important to the Parkinson’s Disease Patient

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Author
Dr. Michael S. Okun

Each year as we move into summer, the Movement Disorders Society holds their annual International Congress where thousands of investigators from all over the world converge in a central location to present the latest research. Each year we keep our eyes open and our ears primed for news on the latest Parkinson’s disease therapies. This year several projects caught our attention. 

Category
What's Hot in PD?

What's Hot in PD? Time for the Parkinson’s Disease Patients to Break Out the Suntan Lotion: Increased Risk of Melanoma in Parkinson’s Disease

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Author
Dr. Michael S. Okun

There is a growing body of evidence supporting the notion that melanoma may have a greater risk of occurring in the setting of Parkinson’s disease.  The latest study was presented at the American Academy of Neurology’s 61st Annual meeting in Seattle, WA.  A cohort of nearly 160,000 patients were followed carefully, and of those patients, 616 developed Parkinson’s disease.  A family history of melanoma roughly doubled the risk of developing Parkinson’s.  Melanoma has additionally been shown to be more common in Parkinson’s disease patients. 

Category
What's Hot in PD?

What's Hot in PD? Finally a DBS Expert Consensus Statement Aimed at Their True Customers: The Patients

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Author
Dr. Michael S. Okun

As the years roll by, too often we continue to preach and throw academic pearls in the general direction of our patients. We preach these pearls and cite their validity by pointing the patient toward well-crafted consensus statements appearing in high impact medical journals. This sterile academic approach has left more than a handful of patients confused in making decisions regarding their own therapy. 

Category
What's Hot in PD?

What's Hot in PD? Pesticides and Environmental Exposures in Parkinson’s Disease: Should We Stay Away From The Stink Truck?

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Author
Dr. Michael S. Okun

When I was a kid we used to ride our bicycles around the neighborhood and in the afternoons we chased one of two trucks; the ice cream truck or the pesticide spraying “stink” truck.  Needless to say, ice cream has not been implicated in causing Parkinson’s disease, however, certain pesticides and environmental exposures have been making the news for possible Parkinson associations.  There has been a recent explosion of research into pesticide exposure and Parkinson’s disease.

Category
What's Hot in PD?

What's Hot in PD? Breaking a Sweat: Is Exercise On Its Way Back Into the Armamentarium for Treatment and Protection Against Parkinson’s Disease?

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Author
Dr. Michael S. Okun

Many years before adequate medication treatments were developed to address the symptoms of Parkinson’s disease, some doctors recommended exercise, staying busy, and when engaging in activities being as “physical” as possible.  There are stories of institutionalized Parkinson’s disease patients (prior to the levodopa era) who were asked to push the chart cart for doctors on rounds, or to fold towels for hospital staff.  Early observations about improvement in Parkinson’s disease patients following task specific physical exertion have contributed to the belief that exercise may be beneficial.

Category
What's Hot in PD?

What's Hot in PD? Why Are Transplant Trials Struggling to Succeed in the Treatment of Parkinson’s Disease?

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Author
Dr. Michael S. Okun

Recently, another transplant trial in Parkinson’s disease was reported as a failure (Spheramine).  It seemed rational many years ago when scientists proposed cell replacement as the penultimate neurorestorative therapy for Parkinson’s disease, but sometimes rational is not enough.  The track record, however has been less than expected.  There have however, been many lessons learned and the experience will hopefully help us toward better therapies in the future.

Category
What's Hot in PD?

What's Hot in PD? Are Rasagiline (Azilect) and other Monoamine Oxidase Inhibitors Disease Modifying or Neuroprotective in Parkinson’s Disease?

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Author
Dr. Michael S. Okun

There has long been interest as to whether monoamine oxidase type B inhibitors may have disease modifying or neuroprotective benefits in Parkinson’s disease(1-4). Disease modifying agents are thought to alter the course or progression of a particular disease. Neuroprotective therapies alternatively provide protection of neurons from neurodegeneration or other injuries (2-4). No therapies to date have been proven to be disease modifying or neuroprotective in Parkinson’s disease patients.

Category
What's Hot in PD?

What's Hot in PD? Update on Gene Therapy for Parkinson’s Disease

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Author
Dr. Michael S. Okun

A common question asked by many patients and families afflicted with Parkinson’s disease is, “what is gene therapy?” Quite simply, gene therapy is placing genetic information (DNA) into the cells and tissues of humans with Parkinson’s disease. In the purest form a defective part of the genome is replaced with a new copy. Perhaps the most interesting part of the evolving story of gene therapy has been the use of a virus as a vector to carry the genetic information into the brain. These viruses have been deactivated and can be safely used for this purpose (1, 2).

Category
What's Hot in PD?

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