Podcast: Substantial Matters

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Every other Tuesday, we bring you a new episode of Substantial Matters: Life and Science of Parkinson’s. Host Dan Keller, PhD, interviews Parkinson’s experts to highlight the treatments and techniques that can help you live a better life now, as well as the research that can bring a better tomorrow. Episodes focus on a range of topics relevant to your daily life, including new levodopa delivery methods, exercise, clinical trials, nutrition and more!

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To get started, listen to the episodes in the following playlist, or learn more about each episode below.

Tell us what you think about the podcast here!

Click here to listen to our Spanish episodes

Podcast Episode 117: Neuropathy: A Non-motor Symptom of Parkinson’s Disease

In this podcast episode, Nurse Practitioner Ellen Walter, MSN, CNP from the Movement Disorders Section of the Center for Neurological Restoration at the Cleveland Clinic in Ohio, a Parkinson’s Foundation Center of Excellence, identifies the general kinds of neuropathies and then focuses on peripheral neuropathies and why it is important to try to identify their causes as a possible path to treatments.

Bonus Episode en Español: Dónde acudir para obtener recursos y apoyo como cuidadores

In our ongoing efforts to reach all communities whose members may be affected by Parkinson's disease, this week's episode will be in Spanish. We will return with more English language podcasts in two weeks. In this episode, Ruby Rendon shares her experiences as a care partner for her mom, and outlines the resources that have helped her navigate her emotional journey as a care partner.

Podcast Episode 116: Caring for Loved Ones with Parkinson’s Disease

In this podcast episode, Jori Fleisher, MD, MSCE of Rush University Medical Center in Chicago, discusses how her team is addressing caregiver needs through a peer mentoring program built into a home visit program. Dr. Fleisher reviews what she and her colleagues have learned so far, how they are refining the program, and where they will go from here, including a large, national, randomized trial of the program.

Podcast Episode 115: Repurposing Medications to Slow Progression of PD

In this podcast episode, Dr. Patrik Brundin, Director of the Parkinson’s Disease Center at Van Andel Institute in Grand Rapids, Michigan, explains the approach of drug repurposing to treat Parkinson’s disease. This approach relies on knowing the mechanisms of the disease and searching through the vast array of current drugs to treat all sorts of conditions and rationally choosing ones that may work to slow progression of PD.

Podcast Episode 114: Gene-Based Therapies for Parkinson’s Disease

In this second part of our series on Parkinson’s disease therapies, Dr. Roger Barker, Professor of Clinical Neuroscience at the University of Cambridge in the United Kingdom, explains gene-based therapy. Dr. Barker discusses plans for the execution of the treatments, what symptoms they are aimed at, where the field currently stands, and how it compares to developments in cell-based therapies.

Podcast Episode 113: Cell-Based Therapies for Parkinson’s Disease

In this podcast episode, Dr. Roger Barker, Professor of Clinical Neuroscience at the University of Cambridge in the United Kingdom, summarizes what has been learned so far about cell-based therapies for treating Parkinson’s disease.

Podcast Episode 112: Non-pharmaceutical Treatments for PD: DBS and Focused Ultrasound

In this podcast episode, Kyle Mitchell, MD of Duke University in North Carolina discusses two non-pharmaceutical treatments for Parkinson's disease: deep brain stimulation (DBS) and focused ultrasound (FUS). Dr. Mitchell discusses how each treatment works, which patients may do best with either of them, and what is in development.

Podcast Episode 111: Alone in a Crowd: Overcoming Isolation

In this podcast episode, Aaron Daley, Coordinator for the Parkinson’s Disease Clinic and Research Center at the University of California, San Francisco, discusses social isolation and ways to overcome it, whether you live in an urban or rural area. He recommends seeking out support, exercising regularly, or establishing a routine of activity with a companion.

Podcast Episode 110: Social Isolation and Loneliness

In this podcast episode, Dr. Indu Subramanian, Director of the Parkinson’s Disease Research, Education and Clinical Center at the West Los Angeles Veterans Affairs Medical Center, discusses loneliness and social isolation and offers suggestions for keeping them at bay.

Podcast Episode 109: Medication Timing

In this podcast episode, Dr. Indu Subramanian, Director of the Parkinson’s Disease Research, Education and Clinical Center at the West Los Angeles Veterans Affairs Medical Center, discusses what has been learned about the timing of the initiation of therapy. She also provides strategies for getting the most benefit from medications.

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