Deep brain stimulation (DBS) is a therapy that has been administered to over 100,000 patients worldwide. The majority of people receiving deep brain stimulation live with a diagnosis of Parkinson’s disease (PD). The technique has been helpful for improving tremor, on-off fluctuations, dyskinesia, and off time. One of the main limitations of deep brain stimulation has been that it requires brain surgery and carries an associated risk of hemorrhage, stroke, infection, and hardware failure.
Should we consider subcutaneous apomorphine infusions for Parkinson’s disease patients who do not want deep brain stimulation or a dopamine pump? There is a growing interest among people with Parkinson’s disease (PD) and families for a “nonsurgical” alternative to deep brain stimulation (DBS) surgery or to Duopa pump therapy. The idea of brain surgery or a feeding tube have been cited as being undesirable for large numbers of PD patients.
Safinamide (Xadago) was approved by the Food and Drug Administration (FDA) for treatment of Parkinson’s disease (PD) medication fluctuations. Safinamide is a pill that when absorbed in the bloodstream travels to the brain and affects dopaminergic and non-dopaminergic systems.
Hope is something that is critical for everyone living with Parkinson’s disease.Hope for improvement in symptoms. Hope for a better life. Hope for a treatment that may one day arrest disease progression or even deliver a cure. We should embrace hope, but we should also protect everyone living with Parkinson’s disease and their family members from emotionally as well as financially draining opportunities which may overpromise and under-deliver.
Over the past two decades, deep brain stimulation (DBS) therapy for patients with Parkinson’s disease (PD) has been extremely successful. It has been estimated that DBS has meaningfully helped tens of thousands of patients worldwide, improving tremor, dyskinesia, on-off fluctuations and several other Parkinson’s symptoms. DBS has however, fallen short in addressing disease progression issues including walking, talking and thinking.
There has long been a fascination about the relationship between welding, mining and Parkinson-like symptoms. In this month’s What’s Hot blog and in my NEJM Journal Watch blog I explore this murky history and relationship. Doctors and health care professionals long ago identified a Parkinson-like syndrome that developed in welders and manganese miners. Manganese, the chemical, has been linked to Parkinson-like symptoms (also referred to as parkinsonism).
Considerable evidence has been mounting in support of a relationship between the gastrointestinal (GI) system and Parkinson’s disease (PD). Many pathologists and neurologists even believe that Parkinson’s may start in the gut, but this view remains speculative. Many GI symptoms, such as constipation, occur as prominent and disabling PD symptoms. In the July 2013 What’s Hot in PD? column, I addressed H.
A surprising fact about Deep Brain Stimulation (DBS) surgery technology is that human DBS leads (the wire implanted in the brain and connected to the neurostimulator) and their four shiny, tiny contacts have not really changed much over the last two decades. One reason for the durability of DBS lead design has been the long-term beneficial effects of using this simple approach.
How to Address Prominent, Caregiver Challenges, NPF and PDF Complete Merger to Form the Parkinson’s Foundation, Parkinson’s Outcomes Project Links Age to Increased Risk, of Caregiver Strain Caregiver Spotlight: Julie Beck, Top Questions and Answers from "Ask the Doctor", Caregiver Tips for Daily Living What’s Hot in Parkinson’s Disease?, Spotlight on Moving Day® Dallas/Fort Worth, Caregiver Self Quiz, NPF Legacy Society
Ted Dawson, PhD, and colleagues at the Johns Hopkins University, a National Parkinson Foundation Center of Excellence, have uncovered a potential new approach to treat Parkinson’s disease (PD). Researchers in Dawson’s laboratory focused on a protein called lymphocyte-activation gene 3, known as LAG3. This protein has been shown to be important in cell to cell transfers of α-synuclein (Lewy bodies), which is a protein found in the brain of a person with PD.