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What's Hot in PD? Is DBS Plus a Viable Future Treatment for Parkinson’s Disease?

Over the past two decades, deep brain stimulation (DBS) A surgical treatment for Parkinson's disease. A special wire (lead) is inserted into a specific area of the brain responsible for movement. The lead is connected to a pacemaker-like device implanted in the chest region. This device creates electrical pulses, sent through the lead, which “stimulate” the brain and control abnormal brain cell activity. therapy for patients with Parkinson’s disease (PD) has been extremely successful. It has been estimated that DBS has meaningfully helped tens of thousands of patients worldwide, improving tremor Involuntary shaking of the hands, arms, legs, jaw or tongue. The typical Parkinson’s tremor is “pill-rolling” – it looks like holding a pill between thumb and forefinger and continuously rolling it around. Some people report an internal tremor, a shaking sensation inside the chest, abdomen or limbs that cannot be seen. Most Parkinson’s tremor is “resting tremor,” which lessens during sleep and when the body part is actively in use., dyskinesiaAbnormal, involuntary body movements that can appear as jerking, fidgeting, twisting and turning movements; frequently caused by dopaminergic medications to treat Parkinson’s., “on-off” fluctuations Changes in the ability to move, often related to medication timing. Also called motor fluctuations. and several other Parkinson’s symptoms. DBS has however, fallen short in addressing disease progression issues including walking, talking and thinking. Scientists have long been enamored with the idea that since DBS is invasive, but relatively safe, it may be possible to use the guide tubes (straws that DBS leads are fed through to precisely place them into the brain) to deliver growth factors and other goodies to improve brain function. There is also evolving interest in developing DBS leads that could be connected to pumps. These pumps could continuously supply factors to the brain while maintaining the electrical current derived from the DBS device. In this month’s What’s Hot column we will introduce the concept of DBS plus.

The May 2016 edition of the Journal of Neurosurgery featured an article by Craig Van Horne and Greg Gerhardt from the University of Kentucky in Lexington. For many years, Craig and Greg have been interested in the delivery of neurotrophic factors as a strategy to restore or improve dopamine A chemical messenger (neurotransmitter) that regulates movement and emotions. cell dysfunction in Parkinson’s. The experiment they devised was simple and clever. They used Schwann cells and neurotrophic factors within these cells from a superficial nerve (the sural nerve) in a patient’s own leg. The team then performed DBS, however before completing the operation they used the guide tubes to inject the nerve cells into the brain. They targeted the substantia nigra An area of the brain, part of the basal ganglia, where cells produce dopamine., one place where cells are known to die in Parkinson disease. Aside from three patients who reported a patch of numbness in the leg, there were no unexpected adverse reaction across all eight patients (Van Horne, 2016). The trial was registered at under NCT01833364. The investigators have now undertaken a second follow-up DBS study: NCT02369003.

This general procedure has been termed DBS plus. The idea of utilizing the DBS delivery system for neurotrophic and other factors is a novel idea. If such a procedure can be shown to improve effectiveness or to slow disease progression this could be an important advance for people with Parkinson’s. The idea of combination therapy for Parkinson’s disease (DBS plus) is something that experts should carefully consider for future trials. The synergy of DBS, medications, trophic factors, stem cells and other therapies may be a homerun for the next generation of therapies. Too often we try one therapy and quit. Another more promising direction may be to combine our field’s bright spots, such as DBS, with other promising therapies (Heath and Heath, 2010).

Selected References:

van Horne CG, Quintero JE, Gurwell JA, Wagner RP, Slevin JT, Gerhardt GA. Implantation of autologous peripheral nerve grafts into the substantia nigra of subjects with idiopathic Parkinson's disease treated with bilateral STN DBS: a report of safety and feasibility. J Neurosurg. 2016 May 6:1-8. [Epub ahead of print] PubMed PMID: 27153166.

Heath C and Heath D. Switch. Crown Business, 2010.

You can find out more about the Parkinson's Foundation National Medical Director, Dr. Michael S. Okun, by also visiting the Center of Excellence, University of Florida Health Center for Movement Disorders and Neurorestoration. Dr. Okun is also the author of the Amazon #1 Parkinson's Best Seller 10 Secrets to a Happier Life and 10 Breakthrough Therapies for Parkinson's Disease. You can read more from Dr. Okun in the What's Hot in PD? archives.

What's Hot in PD?
Thu, 02/02/2017
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