Coenzyme Q10

  • Cells need energy to survive and function.
  • They contain mitochondria, which are “batteries” that produce energy.
  • In Parkinson's disease, there seems to be a disturbance in the function of these batteries.
  • Coenzyme Q10 seems to affect this energy-generating mechanism in cells, although the exact mechanism remains a mystery.
  • A recent study suggested that treatment with 1200 mg/day of Coenzyme Q10 resulted in improvements in measures of motor function over the fixed period of the study when compared to lower doses of the same compound or to a placebo compound.
  • Coenzyme Q10 was also found to be safe in this trial.
  • A larger trial sponsored by NIH and the Parkinson Study Group was ternimated in May 2011 because it showed no neuroprotective benefit or symptomatic benefit of Coenzyme Q10 for people with early Parkinson’s disease. However, this negative finding may help scientists to close in on several possible mechanisms and to focus on a set of more promising drugs and studies.
  • Findings of this study are specific to PD and they do not reflect the possible value Coenzyme Q10 may have in other disorders.

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