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Podcast: Substantial Matters

Every other Tuesday, we bring you a new episode of Substantial Matters: Life and Science of Parkinson’s. Host Dan Keller, PhD, interviews Parkinson’s experts to highlight the treatments and techniques that can help you live a better life now, as well as the research that can bring a better tomorrow. Episodes focus on a range of topics relevant to your daily life, including new levodopa delivery methods, exercise, clinical trials, nutrition and more!

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To get started, listen to the episodes in the following playlist, or learn more about each episode below.

If you would like to suggest a topic for the podcast, or if you have questions or feedback after listening, let us know at

Episode 22: Do You See What I See? Hallucinations and Parkinson’s Disease 

Dr. Joseph Quinn, professor of neurology at the Oregon Health and Science University in Portland, a Parkinson’s Foundation Center of Excellence, discusses hallucinations and how people with PD can deal with it. More Info

Episode 21: What Other Conditions Are Related to Parkinson’s?

Dr. Connie Marras discusses Parkinson’s comorbidities (conditions you have in addition to PD), how to avoid some of them and what to know about drug interactions. More Info

Episode 20: Medical-Community Partnership for Parkinson’s Wellness

Clinical social worker Amy Lemen describes the Wellness Initiative program, what it offers, who can participate and how. More Info

Episode 19: Ask the Parkinson’s Foundation Helpline: Your Exercise Questions Answered

Jill McClure, an information specialist on with the Parkinson's Foundation Helpline, discusses exercise as medicine and her professional insights. More Info

Episode 18: Stall the Fall

Dr. Sotirios A. Parashos discusses the critical, supporting role that a medical team has in helpling live a better life. More Info

Episode 17: Stem Cells and Parkinson’s

Dr. David K. Simon discusses the alpha-synuclein A protein in the human brain that is associated with the development of Parkinson’s. It is the main component of Lewy bodies. protein and links to the development of Parkinson's. More Info

Episode 16: Can an Asthma Drug Prevent Parkinson’s?

Dr. David K. Simon describes what the researchers did and what they found. More Info

Episode 15: Why and How to Participate in Parkinson’s Research

Christine Hunter describes the value of volunteering for clinical trials and how participants view their experiences. More Info

Episode 14: Clinical Trials for Parkinson’s

Tanya Simuni, MD, explains the clinical trials process and describes some ongoing trials, including how the potential new drugs work and why it’s important for people with Parkinson’s to participate in research. More Info

Episode 13: Generic Drugs for Parkinson’s

Dr. Rajesh Pahwa of the University of Kansas describes how generics compare to brand name products and what to look for and look out for. More Info

Episode 12: What We’ve Learned from the Hispanic Parkinson’s Community

Claudia Martinez discusses differences in the access to information across communities and her practices on providing the best possible care to the Hispanic community. More Info

Episode 11: Extending the Reach of Parkinson’s Resources and Services

Aaron Daley of the University of California, San Francisco, describes his center’s outreach efforts and what is needed to bring Parkinson’s resources to underserved and underrepresented communities. More Info

Episode 10: Young-Onset Parkinson’s 101

Elaine Book, MSW, RSW, discusses the particular challenges of YOPD like disclosure, planning for the future, and controlling the disease. More Info

Episode 9: Keys to Driving with Parkinson's

Lissa Kapust, LICSW, discusses the complications of driving while having Parkinson's and a program aimed at assessment in a variety of areas. More Info

Episode 8: A Vaccine for Parkinson's?

Mark Guttman, MD discusses the potential of using vaccines to clear abnormal forms of alpha-synuclein from the brain. More Info

Episode 7: Genetics as a Guide to Neuroprotection in Parkinson's Disease

David K. Simon, MD, PhD, explains how modern genetics can be a guide to developing new drugs for Parkinson's. More Info

Episode 6: New Levodopa Delivery Methods for Parkinson’s

More than 50 years after its discovery, levodopa is still the most effective treatment for Parkinson’s, but some people experience “off” periods or dyskinesias with oral medications. Dr. Mark Guttman describes new delivery methods that promise to help with some of these problems, especially for people who have had Parkinson’s for many years. More Info

Episode 5: How to Manage Parkinson’s “Off” Time

Parkinson’s can be unpredictable – symptoms can come and go or get better and worse throughout the day. These so-called “on-off” fluctuations (also called motor fluctuations) and dyskinesias can be troubling, but movement disorder specialists can help with the choice of medication, dosages, and timing. Dr. Irene Malaty explains more about what causes these changes and how you can work with your doctor to manage them. More Info

Episode 4: The Importance of Good Nutrition for People with Parkinson’s

Nutrition is increasingly part of the conversation when it comes to good Parkinson's care. Dr. Bas Bloem describes how diet can help improve some of the symptoms of Parkinson's and optimize the effects of medication, and he offers tips on getting adequate nutrition. More Info

Episode 3: The Benefits of Exercise for People with Parkinson's

Regular exercise is essential for people with Parkinson's. Dr. Bas Bloem describes what is known about exercise and PD and what is still in the research stages, and he offers some tips on overcoming barriers to getting enough exercise. More Info

Episode 2: The Parkinson's Foundation’s Role in Improving Standards of Care

Dr. Peter Schmidt of the Parkinson’s Foundation explains where people with Parkinson’s can go to receive the best interdisciplinary care and how the Foundation is improving standards of Parkinson’s care around the world. The Foundation's Centers of Excellence network and the Parkinson's Outcomes Project are key aspects of the discussion. More Info

Episode 1: Early Warning Signs of Parkinson's

In this debut episode of Substantial Matters: Life and Science of Parkinson's, Dr. Michael Okun talks about early warning signs of Parkinson's and offers practical advice on how to proceed after a diagnosis. More Info

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